Postnatal Growth Responses to Insulin-Like Growth Factor I in Insulin Receptor Substrate-1-Deficient Mice1
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چکیده
منابع مشابه
Postnatal Growth Responses to Insulin-Like Growth
Organ weight was compared in adult mice with deletion of one (IRS-1) or both (IRS-1) copies of the insulin receptor substrate-1 (IRS-1) gene and IRS-1 littermates. IRS-1 mice showed modest reductions in weight of most organs in proportion to a decrease in body weight. IRS-1 mice showed major reductions in weight of heart, liver, and spleen that were directly proportional to a decrease in body w...
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Insulin-like growth factor I gene polymorphism associated with growth traits in beluga (Huso huso) fish
The aim of the present study was to detect polymorphism in Insulin like growth factor-I (IGF-I) gene of beluga (Huso huso) fish using PCR-SSCP technique and also investigation of its association with growth traits (condition factor, body length and weight). A total of 150 specimens of beluga were randomly selected and DNA was isolated from caudal fin using modified salting out method. Then two ...
متن کاملInsulin-like growth factor I gene polymorphism associated with growth traits in beluga (Huso huso) fish
The aim of the present study was to detect polymorphism in Insulin like growth factor-I (IGF-I) gene of beluga (Huso huso) fish using PCR-SSCP technique and also investigation of its association with growth traits (condition factor, body length and weight). A total of 150 specimens of beluga were randomly selected and DNA was isolated from caudal fin using modified salting out method. Then two ...
متن کاملInsulin-like growth factor I is essential for postnatal growth in response to growth hormone.
Insulin-like growth factor I (IGF-I) is essential for cell growth and intrauterine development while both IGF-I and GH are required for postnatal growth. To explore the possibility of direct GH action on body growth, independent of IGF-I production, we have studied the effects of GH in an IGF-I-deficient mouse line created by the Cre/loxP system. The IGF-I null mice are born with 35% growth ret...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1999
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.140.12.7219