Pluripotent stem cell-derived hepatocyte-like cells
نویسندگان
چکیده
منابع مشابه
Pluripotent stem cell-derived hepatocyte-like cells.
Liver disease is an important clinical problem, impacting over 30 million Americans and over 600 million people worldwide. It is the 12th leading cause of death in the United States and the 16th worldwide. Due to a paucity of donor organs, several thousand Americans die yearly while waiting for liver transplantation. Unfortunately, alternative tissue sources such as fetal hepatocytes and hepati...
متن کاملefficient differentiation of human induced pluripotent stem cell (hipsc) derived hepatocyte-like cells on hmscs feeder.
background: the use of stem cells is considered as an appropriate source in cell therapy and tissue engineering. differentiation of human induced pluripotent stem cells (hipscs) to hepatocyte-like cells (hlcs) on mouse embryonic fibroblasts (mefs) feeders is confronted with several problems that hinder the clinical applications of these differentiated cells for the treatment of liver injuries. ...
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Background: Wharton’s jelly is an unlimited source of stem cells that can be used in cell therapy and tissue engineering without any ethical concern. It has been revealed the cell-free extract could be effective to induce cell differentiation. The objective of this study was to induce Wharton’s jelly-derived mesenchymal stem cells (MSCs) into hepatocyte-like cells by premeabilization of the cel...
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BACKGROUND The use of stem cells is considered as an appropriate source in cell therapy and tissue engineering. Differentiation of human induced Pluripotent Stem Cells (hiPSCs) to Hepatocyte-like Cells (HLCs) on mouse embryonic fibroblasts (MEFs) feeders is confronted with several problems that hinder the clinical applications of these differentiated cells for the treatment of liver injuries. S...
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ژورنال
عنوان ژورنال: Biotechnology Advances
سال: 2014
ISSN: 0734-9750
DOI: 10.1016/j.biotechadv.2014.01.003