Phytohemagglutinin (PHA)-induced transformation of lymphocytes from patients with cancer

Quantitative dinitrochlorobenzene (DNCB) responsivity and phytohemagglutinin (PHA) induced lymphocyte transformation in patients with lepromatous leprosy.

The response to phytohaemagglutinin (PHA) of lymphocytes from cancer patients.

The uptake of tritiated thymidine by lymphocytes from 100 cancer patients and 31 normal subjects was tested in the presence and absence of phytohaemagglutinin (PHA) in a medium containing autologous or homologous serum. Significant differences were found between normal subjects and cancer patients in both the time course and degree of uptake. Serum from normal individuals restored the response ...

The ultrastructure of phytohemagglutinin (PHA) stimulated lymphocytes of chronic lymphatic leukemia.

By KATHRYN P. CLAUSEX AND BERTHA A. BOURONCLE P HYTOHEMAGGLUTININ ( PHA) is a potent mitogen, capable of stimulating lymphocyte transformation to blastoid or mitotic cells in vitro.1’2 Lymphocytes from patients with chronic lymphatic leukemia ( CLL ) are hyporesponsive or have a delayed response to PHA stimulation under the conditions of the usual short-term culture.35 In a separate study5 the ...

Improvement of phytohemagglutinin responsiveness of lymphocytes from cancer patients after washing in vitro.

phocytes from a simultaneously studied normal control in dividual. After one in vitro washing, it was found that the lymphocytes of 14 of the 23 cancer patients were sup pressed in their response to PHA, at at least 1 PHA dosage, as indicated by a proliferative response of less than one-half of that of control lymphocytes (measured by incorporation of [3H]thymidine). These suppressed cancer pat...

Studies of the delayed response of phytohemagglutinin (PHA) stimulated lymphocytes in 25 chronic lymphatic leukemia patients before and during therapy.