Phenytoin dosage adjustment method using population clearance.
نویسندگان
چکیده
منابع مشابه
Warfarin dosage adjustment strategy in Chinese population.
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Phenytoin dosing is often difficult in a clinical situation because of the non-linear nature of phenytoin metabolism at therapeutic plasma concentrations. This study was performed to examine retrospectively five pharmacokinetic methods of adjusting phenytoin dosage based on a single steady-state plasma phenytoin concentration-dose pair in 66 epileptic Chinese children and adults. The methods co...
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Blood phenytoin (diphenylhydantoin) concentrations were measured after each dosage change in 12 epileptic patients who were given increasing oral doses of phenytoin. In each of these patients a dosage increment beyond the dosage that produced a blood phenytoin level of 6-9 μg/ml. caused a disproportionately great increase in the blood concentration of drug. This effect might be expected if the ...
متن کاملReply: "Dosage adjustment for hepatic dysfunction".
In relation to the letter, we wish to make the following clarifications: As the authors of the letter showed their search was carried out using different criteria and time periods. In our case the dosage recommendations were established in those drugs included in the Pharmacotherapy guide (GFT) of the hospital that were susceptible to adjustment in patients with CLD based on the information obt...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1990
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.38.510