Phenobarbital Augments Hypothermic Neuroprotection
نویسندگان
چکیده
منابع مشابه
Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model.
Despite treatment with therapeutic hypothermia, almost 50% of infants with neonatal encephalopathy still have adverse outcomes. Additional treatments are required to maximize neuroprotection. Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions against hypoxic-ischaemic brain injury in animal models. The objective of this study was...
متن کاملMechanisms of hypothermic neuroprotection.
Prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of delayed cell death can reduce acute brain injury and improve long-term behavioral recovery in term infants and in adults after cardiac arrest. The specific mechanisms of hypothermic neuroprotection remain unclear, in part because hypothermia su...
متن کاملDocosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model.
BACKGROUND In neonatal rats, early post-hypoxia-ischemia (HI) administration of the omega-3 fatty acid docosahexaenoic acid (DHA) improves sensorimotor function, but does not attenuate brain damage. OBJECTIVE To determine if DHA administration in addition to hypothermia, now standard care for neonatal asphyxial brain injury, attenuates post-HI damage and sensorimotor deficits. METHODS Seven...
متن کاملUpdate on Techniques for Neuroprotection during Hypothermic Arrest
Surgical repair of the ascending aorta and aortic arch that employs cardiopulmonary bypass (CPB), often with the use of deep hypothermic circulatory arrest (DHCA), allows for lifesaving therapy. In doing so, however, it also represents a unique injury paradigm leading to derangements in numerous homeostatic pathways. Organ injury, most notably cerebral injury, may result as a consequence of the...
متن کاملIs a hypothermic effect of LY300164, valproate and phenobarbital evident in mice?
PURPOSE The aim of this study was to evaluate the influence of LY300164 (an AMPA/kainate receptor antagonist) administered alone or in combination with valproate (VPA) or phenobarbital (PB) on body temperature in mice. MATERIAL AND METHODS The temperature measurements were performed in Albino Swiss mice injected with the respective drugs by using a rectal thermistor thermometer. RESULTS LY3...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2010
ISSN: 0031-3998,1530-0447
DOI: 10.1203/pdr.0b013e3181d4ff4d