Pharmacokinetic and Pharmacodynamic Studies of Tulathromycin in Buffalo Calves
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چکیده
منابع مشابه
Pharmacokinetic‐pharmacodynamic integration of enrofloxacin and its metabolite ciprofloxacin in buffalo calves
The present study was planned with an objective to test the pharmacokinetics of a new formulation of enrofloxacin (Flobac® SA) in buffalo calves. The drug was administered at the dose rate of 7.5 mg kg-1 body weight through the intravenous (i.v.) and intramuscular (i.m.) route followed by plasma collection and analysis at different time intervals. After analysis, using High Performance Liquid C...
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Florfenicol was administered subcutaneously to 10 calves at a dose of 40 mg/kg. Pharmacokinetic-pharmacodynamic (PK-PD) integration and modelling of the data were undertaken using a tissue cage model, which allowed comparison of microbial growth inhibition profiles in three fluids, serum, exudate and transudate. Terminal half-lives were relatively long, so that florfenicol concentrations were w...
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Greko, C. 2003. Tissue cages in calves for studies on pharmacokinetic/pharmacodynamic relationships of antimicrobials. Doctor’s dissertation ISSN 1401-6257, ISBN 91-567-6373-4 Knowledge on pharmacokinetic/pharmacodynamic (PK/PD) relationships of antimicrobials may assist in defining a dose that maximises effect while minimising side effects such as selection of resistance. The aim of this thesi...
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Tulathromycin, a macrolide antibiotic, is used for the treatment of respiratory disease in cattle and swine. The aim of our study was to investigate the in vitro and ex vivo activities of tulathromycin in serum, (non-inflamed) transudate, and (inflamed) exudate against Pasteurella multocida in piglets. The pharmacokinetics properties of tulathromycin were studied for serum, transudate, and exud...
متن کاملPharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves.
In a four-period, cross-over study, the fluoroquinolone antibacterial drug marbofloxacin (MB) was administered to calves, alone and in combination with the nonsteroidal anti-inflammatory drug tolfenamic acid (TA). Both drugs were administered intramuscularly (IM) at doses of 2 mg/kg. A tissue cage model of inflammation, based on the actions of the mild irritant carrageenan, was used to evaluate...
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ژورنال
عنوان ژورنال: Zagazig Veterinary Journal
سال: 2013
ISSN: 2357-075X
DOI: 10.21608/zvjz.2013.95690