Pharmacodynamics of non-depolarizing muscle relaxants in rat model with chronic renal failure
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چکیده
منابع مشابه
Different magnitude of resistance to non-depolarizing muscle relaxants in dexamethasone-treated rat diaphragm associated with altered acetylcholine receptor expression.
The aim of this study was to investigate the influence of chronic dexamethasone (Dex) administration on rat diaphragm sensitivity to non-depolarizing muscle relaxants (NDMRs) and muscular nicotinic acetylcholine receptor (nAChR) expression, which may help direct future administration of NDMRs. Adult male Sprague-Dawley rats were randomized to receive a daily intraperitoneal injection of Dex (60...
متن کاملPharmacodynamics of non-depolarizing neuromuscular blocking agents.
When a clinical dose of a competitive neuromuscular blocking drug is given I.V. to a patient, a period of latency is followed by a progressive onset of blockade until a maximum is reached after several minutes. Thereafter, the intensity of block declines gradually. The precise relationship between the dose of drug and the time-course of the effect is complex, being dependent upon both pharmacok...
متن کاملDenervation supersensitivity: the response to depolarizing muscle relaxants.
The chemical theory of neuromuscular transmission (Dale, Feldberg and Vogt, 1936) is now almost universally accepted, and implicates acetylcholine as the neuromuscular transmitter. Depolarizing muscle relaxants act, at least initially, in a manner similar to acetylcholine and are believed to produce their effects by prolonged depolarization, but in certain situations these agents, instead of pr...
متن کاملChanges in resistance to mouth opening induced by depolarizing and non-depolarizing neuromuscular relaxants.
Mouth opening was measured in 43 children anaesthetized with isoflurane and paralysed with vecuronium or suxamethonium. Measurements of mouth opening were made for up to 10 min after loss of the adductor pollicis twitch and cessation of muscle fasciculations. In 22 patients receiving suxamethonium, a significant (P less than 0.001) reduction in mean mouth opening occurred in the 60 s after loss...
متن کاملAssociation of hemodialysis and pruritus in chronic renal failure
Background and aim: Pruritus is a common disabling problem in patients with end stage renal disease. Several studies has recorded the relation between pruritus with hemodialysis in chronic renal failure (CRF) patients. This study was designed to evaluate the effect of hemodialysis on pruritus of patients with CRF.Materials and Methods: After recording the demographic data and the diagnosis of d...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1991
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.103.5-6_573