Pentoxifylline and tumour necrosis factor-induced lung injury
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چکیده
منابع مشابه
Pentoxifylline and tumour necrosis factor-induced
Acute Gram-negative bacterial infections evoke characteristic pathophysiological responses, including changes in white blood cell counts, fever, haemodynamic disorders, and various coagulatory disturbances, which may result in respiratory distress syndrome, multiorgan failure and irreversible shock. It is generally accepted that endotoxins, the lipopolysaccharides (LPS) of Gramnegative bacteria...
متن کاملLung and gut injury induced by tumour necrosis factor.
Piguet, P.F., Grau, G.E. & Vassalli, P. (1990). Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis. Am. J. fathot., 136, 103-I 10. Piguet, P.F., Grau, G.E., Allet, B. & Vassalli, P. (1987), Tumor necrosis factor is an effector of skin and gut lesions of the acute phase of graft-versus-host dise...
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Neutrophil adherence within the gastric microcirculation is thought to be a major step in the pathogenesis of gastric mucosal damage induced by indomethacin. Pentoxifylline, a methylxanthine derivative, prevents leukocyte adherence to vascular endothelium and protects organs from shock by reducing tumour necrosis factor alpha (TNF alpha) concentrations. Rats were treated with 20 mg/kg oral indo...
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BACKGROUND The death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) shows considerable clinical promise as a therapeutic agent. TRAIL induces leukocyte apoptosis, reducing acute inflammatory responses in the lung. It is not known whether TRAIL modifies chronic lung injury or whether TRAIL has a role in human idiopathic pulmonary fibrosis (IPF). We therefore exp...
متن کاملSignal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.
Many biological functions are regulated through interactions of extracellular molecules with their cognate cell surface receptors. The transduction of these signals by their receptors at the plasma membrane to the intracellular machinery results in such cellular activities as gene activation, protein phosphorylation, cell proliferation, and cell destruction. Though the kinetics of these activit...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 1994
ISSN: 0000-0000,0903-1936
DOI: 10.1183/09031936.94.07081389