Pathogenesis of autoimmunity.

Xenogeneic Thymus Transplantation Pathogenesis of Autoimmunity After

Pathogenesis of autoimmunity in common variable immunodeficiency

Common variable immunodeficiency (CVID) presents in up to 25% of patients with autoimmune (AI) manifestations. Given the frequency and early onset in some patients with CVID, AI dysregulation seems to be an integral part of the immunodeficiency. Antibody-mediated AI cytopenias, most often affecting erythrocytes and platelets make up over 50% of these patients. This seems to be distinct from mai...

Autoimmunity and the pathogenesis of myocarditis.

T he ability to distinguish between self versus nonself is the most salient feature of the immune system. It is of vital importance for the immune system to mount vigorous humoral and cellular responses to foreign antigens. On the other hand, it is equally important for the immune system to be tolerant against self-antigens. Tolerance can be maintained either by physical elimination (clonal del...

Pathogenesis of Chagas heart disease: role of autoimmunity.

Chagas heart disease is caused by infection with the protozoan parasite Trypanosoma cruzi. The apparent absence of parasites from the hearts of most individuals who succumb to this illness has led some to propose an autoimmune basis for disease pathogenesis. This hypothesis has been extremely difficult to test, because other mechanisms of tissue inflammation may coexist in the setting of active...

Pathogenesis and therapy of autoimmunity-induced dilated cardiomyopathy.

Myocarditis and dilated cardiomyopathy can potentially originate from autoimmune responses. Although genetic predisposition, viral infection, molecular mimicry, and oxidative stress are potential contributing factors to dilated cardiomyopathy, the underlying mechanism (s) has not been fully elucidated. Autoantibodies (AABs) against cardiotropic targets such as ss-adrenergic receptors, mitochond...