Parametric Methods for Dynamic 11C-Phenytoin PET Studies

Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies

Objective(s): Phenytoin is an antiepileptic drug that is used worldwide. The whole-body pharmacokinetics of this drug have been extensively studied using 11C-phenytoin in small animals. However, because of the limited production amounts that are presently available, clinical 11C-phenytoin PET studies to examine the pharmacokinetics of phenytoin in humans have not yet been performed. We aimed to...

Novel parameter estimation methods for 11C-acetate dual-input liver model with dynamic PET.

The successful investigation of 11C-acetate in positron emission tomography (PET) imaging for marking hepatocellular carcinoma (HCC) has been validated by both clinical and quantitative modeling studies. In the previous quantitative studies, all the individual model parameters were estimated by the weighted nonlinear least squares (NLS) algorithm. However, five parameters need to be estimated s...

Validation of parametric methods for [11C]PE2I positron emission tomography

OBJECTIVES The radioligand [(11)C]PE2I is highly selective for dopamine transporter (DAT) and can be used in vivo for investigation of changes in DAT concentration, progression of disease and validation of treatment using positron emission tomography (PET). DAT is an important protein for regulation of central dopamine concentration and DAT deficiency has been associated with several neurodegen...

Dynamic PET/CT with 11C-acetate in prostate cancer.

Parametric [11C]flumazenil images.

OBJECTIVE This [11C]flumazenil (FMZ) study evaluates the performance of various parametric analysis methods and their ability to detect statistically significant group differences. METHODS Dynamic 60-min FMZ scans were performed in eight healthy and nine individuals with major depressive disorder. Parametric volume of distribution (VT) images were generated using a basis function method (BFM)...