Pachymeningitis and Aortitis in a Patient With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

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HLA-B52-positive Aortitis with Antineutrophil Cytoplasmic Antibody-associated Vasculitis

A 73-year-old man presented with a 1-month history of fever and numbness of the bilateral upper and lower extremities. Laboratory tests showed positive myeloperoxidaseantineutrophil cytoplasmic antibody (ANCA) results (296 U/ mL). Computed tomography (CT) showed wall thickening in the thoracic aorta and common carotid arteries (Picture A), and gallium single-photon emission CT/CT showed accumul...

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Myeloperoxidase antineutrophil cytoplasmic autoantibody-associated glomerulonephritis in a very elderly patient with generalized vasculitis at autopsy.

An 86-year-old woman was admitted with hemoptysis and rapid deterioration of renal function. Renal biopsy disclosed necrotizing crescentic glomerulonephritis. Based on positivity for serum myeloperoxidase antineutrophil cytoplasmic autoantibody (MPO-ANCA), MPO-ANCA-associated glomerulonephritis was diagnosed. Steroid pulse therapy was performed, but the patient died after the second course. Aut...

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IgG4-related hypertrophic pachymeningitis coexpressing antineutrophil cytoplasmic antibodies

IgG4 disease was first described in 2001 in a seminal paper by Hamano and colleagues: Syndrome of exocrine gland infiltration with associated raised serum IgG4 levels. IgG4 disease is manifested by the hallmark histopathologic features of lymphoplasmacytic infiltration of IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. Hypertrophic pachymeningitis (HP) has been incre...

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Treatment of antineutrophil cytoplasmic antibody-associated vasculitis.

PURPOSE OF REVIEW The primary idiopathic small-vessel vasculitis syndromes include granulomatosis with polyangiitis, Churg-Strauss syndrome, and microscopic polyangiitis. These disorders are commonly referred to as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides and prominently affect the pulmonary vasculature. Although significant progress has been made in the management of ...

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Antineutrophil Cytoplasmic Antibody Vasculitis Associated with Influenza Vaccination

Background: Administration of influenza vaccines has been associated with the development of autoantibodies and autoimmune rheumatic disease. Patients: We discuss 2 patients who developed antineutrophil cytoplasmic antibody-associated vasculitis (AAV) in temporal association with influenza immunization. AAV was diagnosed 2 and 4 weeks after immunization in these patients. Both patients had rena...

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ژورنال

عنوان ژورنال: Mayo Clinic Proceedings

سال: 2014

ISSN: 0025-6196

DOI: 10.1016/j.mayocp.2014.03.021