P4-057: Efficacy of Fluorescence-Labelled Amyloid-Beta1-42 on Microglial Activation
نویسندگان
چکیده
منابع مشابه
Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus.
Amyloid-beta (Abeta) is causally implicated in Alzheimer's disease and neuroplasticity failure has acquired validity as a possible mechanism of early AD pathogenesis. We have previously demonstrated that oligomeric Abeta(1-42) inhibits LTP in the dentate gyrus of rat hippocampal slices. We now show, using whole cell recordings in hippocampal granule cells, that oligomeric Abeta(1-42) decreases ...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2016
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2016.06.2147