P-176 Is there a relationship between ovarian reserve, oocyte and embryo quality in patients undergoing PGT-A?

Abstract Study question Is there a relationship between ovarian reserve, oocyte and embryo quality in patients undergoing PGT-A? Summary answer Our data revealed no percentage of aneuploid blastocysts with hormonal signs reduced reserve. What is known already Poor as determined by serum anti-mullerian hormone (AMH) antral follicle count (AFC) levels, risk factor for poor outcomes vitro fertilization (IVF). Ultrasound imaging considered to be the most reliable method measuring it provides direct accurate assessment number follicles. However, reserve not well understood, further research needed fully understand implications these test results IVF outcomes. design, size, duration The present retrospective case-control study, performed 2015 2021, aims investigate association ORTs rate euploid embryos conceived through ICSI. 680 underwent procedures that included blastocyst biopsy 23-chromosome aneuploidy testing. Regardless cycle day, level greater than 1,2 ng/mL was regarded normal, less 10 follicles total were associated diminished according current knowledge. Participants/materials, setting, methods AMH AFC studied determine their rates abnormal development. Patients divided into two groups based on baseline levels. group (n = 680) had 562 individuals normal Group 1 118 lower 2. A similar division made same values, resulting 210 low 348 AFC. Main role chance Low up slightly older patients, would expected (39,9 compared 40,41 years 1; P 0,193). shown FSH levels significantly higher (P 0,022) those ones. Not surprisingly, aspirated follicles, oocytes retrieved, pre-ovulatory fertilizable oocyte, fertilized evolutionary appeared people (respectively P<0,01; 0,004; 0,013; 0,009; 0,015). This means latter better even though they comparable non-evolutionary mean 0,047). Regarding embryos, didn’t result statistically significant difference 2 0,14) cohort 0,12) cohort. We obtained almost taking account As expected, regarding protocols gonadotropins used stimulate women, our value 0,016) due personalized women predicted or normal/high responders. Limitations, reasons caution There are many points affecting (DOR), linked variety etiologies. genetic determinants DOR remain largely unknown. All features don’t allow making an easy model studying this condition. Wider findings study can help clinics provide more informative counseling IVF, giving them understanding factors affect chances success how impact treatment. Trial registration None