Oxycodone‐induced neuronal degeneration (803.1)

Neuronal degeneration and mitochondrial dysfunction.

Neuronal degeneration in canine narcolepsy.

Narcolepsy is a lifelong illness characterized by persistent sleepiness, hypnagogic hallucinations, and episodes of motor paralysis called cataplexy. We have tested the hypothesis that a transient neurodegenerative process is linked to symptom onset. Using the amino-cupric silver stain on brain sections from canine narcoleptics, we found elevated levels of axonal degeneration in the amygdala, b...

Diabetes Mellitus Type1 and Neuronal Degeneration in Ventral and Dorsal Hippocampus

  Background and Objectives: Studies have documented the morhplogical, neurochemical and functional difference between the dorsal and ventral zones of hippocampus. The aim of this study was to assess the effects of chronic diabetes mellitus type1 on ventral and dorsal zones of hippocampus. Methods: Experimental diabetes was induced by stereptozotocin at a dose of 60 mg/kg. At the end of 8 wee...

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

with heterotrimeric G proteins (Nishimoto et al., 1993), Alzheimer’s disease (AD) is the most common cause of and APPs can activate high conductance potassium progressive cognitive decline in the aged population. channels (Furukawa et al., 1996) and increase the activThe triad of amyloid plaques, neurofibrillary tangles, and ity of MAP kinase (Greenberg et al., 1994). However, the dementia that...

O6: Protective Effect of Alpha-Lipoic Acid on Neuronal Degeneration Due to Sciatic Nerve Transection in Rat

Peripheral nerve injury induces inflammation and oxidative stress, which are the most significant causes of the neuronal death. Alpha Lipoic acid (ɑ-LA) as a potent antioxidant and anti-inflammatory agent may counteract the oxidative stress and inflammatory response. This study was designed to investigate the protective effect of ɑ-LA on neuronal cell death in L4 dorsal root ganglion (L4-DRG) i...