Oxybutynin topical gel in the treatment of overactive bladder
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چکیده
منابع مشابه
Oxybutynin topical gel in the treatment of overactive bladder
Overactive bladder (OAB), often accompanied by urinary incontinence, is most prevalent among the elderly, but also affects many middle-aged men and women in the US. OAB may severely impair quality of life, and its overall economic costs to society are substantial. Although antimuscarinic agents relieve OAB symptoms effectively, treatment persistence generally is low. This has been attributed in...
متن کاملDevelopment of oxybutynin chloride topical gel for overactive bladder
Overactive bladder (OAB) is an age-related syndrome often associated with urinary incontinence. Symptoms of OAB, such as urgency, frequency, and nocturia, can be treated effectively with inhibitors of muscarinic acetylcholine receptors. Antimuscarinic agents promote relaxation of the detrusor muscle and may modulate afferent neuronal signals involved in the regulation of the micturition reflex....
متن کاملEfficacy and safety of oxybutynin chloride topical gel for women with overactive bladder syndrome.
OBJECTIVE This subgroup analysis of a phase-3 study evaluated the efficacy and safety of oxybutynin chloride topical gel (OTG) in women with overactive bladder syndrome (OAB). STUDY DESIGN Women (n = 704) with urgency-predominant urinary incontinence received OTG or placebo for 12 weeks. The primary endpoint was change from baseline to last observation in number of daily incontinence episodes...
متن کاملTransdermal oxybutynin in the treatment of overactive bladder
Overactive bladder is a dreadful syndrome that affects a considerable number of patients. Antimuscarinics are the mainstay of pharmacotherapy for this condition. Transdermal (TD) oxybutynin (OXY) bypasses the first-pass metabolism and reduces the formation of N-desethyloxybutynin, a compound believed to be associated with anticholinergic side effects. The 3.9 mg matrix TD system is applied twic...
متن کاملoxybutynin and tolterodine in a trial for treatment of overactive bladder in iranian women.
objective: to evaluate the efficacy and side effects of oxybutinin in comparison to tolterodine in treatment of overactive bladder (oab) with detrussor overactivity (doa) in iranian women. materials and methods: one hundred iranian old women with clinical symptoms of oab who show ido in the filling cystometry participated in this randomized double-blinded parallel-group by using two kinds of th...
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ژورنال
عنوان ژورنال: Research and Reports in Urology
سال: 2010
ISSN: 2253-2447
DOI: 10.2147/rru.s5668