Oxidative Damage and Cancer

Oxidative damage and carcinogenesis

Oxygen is an essential element to conduct life processes but some of the metabolic byproducts e.g. reactive oxygen species (ROS), are toxic for living organisms. Endogenous ROS are produced e.g. reduction of dioxygen; some exogenous sources of radicals also exist, including nicotine and ionizing radiation. Reactive oxygen species include superoxide anion, hydroxyl radical, singlet oxygen, hydro...

The molecular epidemiology of oxidative damage to DNA and cancer.

Oxygen is required for respiration and the energetic processes that enable aerobic life. A cost associated with oxygen use is free-radical formation, which damages genome stability and contributes to various processes including aging, degenerative diseases, and cancer (1,2). Foods including fruits, vegetables, tea components, and trans-fats; nutrients including vitamins C and E, selenium, beta-...

Pancreatic Cancer is Associated with Peripheral Leukocyte Oxidative DNA Damage

Background: DNA damage accumulation has been linked to the cancer phenotype. The purpose of this study was to compare the levels of DNA base 8-hydroxy-2′-deoxyguanosine (8-OHdG) and C-reactive protein (CRP) inflammatory markers in healthy controls and pancreatic cancer patients from a hospital-based case-control study. Materials and Methods: Fifty-five pancreatic cancer patients and 55 healthy ...

Oxidative Damage and Bronchial Asthma

Free Radicals, Oxidative Stress and Oxidative Damage in Parkinson's Disease

Parkinson’s disease (PD) is an adult-onset disease of unknown etiology, with a prevalence of 0.3% in the entire population, affecting more than 1% of humans over 60 years of age. Primary degeneration occurs in pigmented dopamine-containing neurons in the pars compacta of the substantia nigra, with projections to the striatum and typical motor signs that appear with a loss of 60% of the dopamine...