Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders
نویسندگان
چکیده
منابع مشابه
Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders
Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron deficiency causes anemia, a major public health burden worldwide. On the other extreme, iron accumulation in critical organs such as liver, heart, and pancreas causes organ dysfunction due to the generation...
متن کاملIron and aluminum homeostasis in neural disorders.
The brain is the most compartmentalized organ. It is also highly aerobic. Because nerve cells grow but do not regenerate, the brain is the organ best suited for the accumulation of metabolic errors colocalized in specific areas of the brain over an extended period. Alzheimer's disease (AD) is primarily a neurological disorder of the elderly. It is suggested that this disorder results from the a...
متن کاملSystemic and Cerebral Iron Homeostasis in Ferritin Knock-Out Mice
Ferritin, a 24-mer heteropolymer of heavy (H) and light (L) subunits, is the main cellular iron storage protein and plays a pivotal role in iron homeostasis by modulating free iron levels thus reducing radical-mediated damage. The H subunit has ferroxidase activity (converting Fe(II) to Fe(III)), while the L subunit promotes iron nucleation and increases ferritin stability. Previous studies on ...
متن کاملIroning out the problem: new mechanisms of iron homeostasis.
For most organisms, iron is an essential nutrient that is both difficult to acquire from the environment and toxic at high concentration. Therefore, to avoid deprivation or over-abundance of iron, bacteria and eukaryotes have developed a tight regulatory system to keep the metal within a narrow concentration range. Recent work in the bacteria Escherichia coli and in Pseudomonas aeruginosa has d...
متن کاملReview in translational hematology Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
Genetic analysis of hemochromatosis has led to the discovery of a number of genes whose mutations disrupt iron homeostasis and lead to iron overload. The introduction of molecular tests into clinical practice has provided a tool for early diagnosis of these conditions. It has become clear that hemochromatosis includes a spectrum of disorders that range from simple biochemical abnormalities to c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nutrients
سال: 2013
ISSN: 2072-6643
DOI: 10.3390/nu5083034