Optimized tuning of TALEN specificity using non-conventional RVDs
نویسندگان
چکیده
منابع مشابه
Optimized tuning of TALEN specificity using non-conventional RVDs
A key feature when designing DNA targeting tools and especially nucleases is specificity. The ability to control and tune this important parameter represents an invaluable advance to the development of such molecular scissors. Here, we identified and characterized new non-conventional RVDs (ncRVDs) that possess novel intrinsic targeting specificity features. We further report a strategy to cont...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep08150