منابع مشابه
On mice, rabbits, and human heart failure.
Sarcomeres, bundled into thick and thin filaments, are the units of contraction in the striated muscle. The thick filaments comprise several hundred hexameric myosin molecules, composed of 2 myosin heavy chain (MyHC) proteins, the molecular motor of contraction, and 2 regulatory and 2 essential light chains. The globular head of MyHC contains the binding domains for cardiac -actin and adenosine...
متن کاملComparison of the effects of intramyocardial and intravenous injections of human mesenchymal stem cells on cardiac regeneration after heart failure
Objective(s): Existing studies have demonstrated that intravenous and intramyocardial-administrated mesenchymal stem cells (MSCs) lead to tissue repair after cardiac disorders. We compared the efficiency of both administration methods.Materials and Methods: A rat model of isoproterenol-induced heart failure (ISO-HF) was established to co...
متن کاملMechanism of congestive heart failure following aorta constriction in rabbits.
Severe constriction of the abdominal aorta in rabbits caused congestive heart failure and death in 4 to 7 days. Expansion of total plasma volume suggested that aortic narrowing increases the vascular bed distal to the stricture. Reduction of total body fluids did not prevent total plasma volume expansion, unless it caused severe dehydration. A large percentage of dietary sodium was retained. Ex...
متن کاملExercise training improves peripheral chemoreflex function in heart failure rabbits.
An enhancement of peripheral chemoreflex sensitivity contributes to sympathetic hyperactivity in chronic heart failure (CHF) rabbits. The enhanced chemoreflex function in CHF involves augmented carotid body (CB) chemoreceptor activity via upregulation of the angiotensin II (ANG II) type 1 (AT(1))-receptor pathway and downregulation of the neuronal nitric oxide synthase (nNOS)-nitric oxide (NO) ...
متن کاملThe production of experimental congestive heart failure in rabbits.
Observations were made on blood pressure, heart size, and physiologic state of 33 rabbits subjected to severe constriction of the abdominal aorta. Two-thirds of the rabbits developed symptoms of congestive heart failure and died within two weeks. Autopsy findings revealed acute passive congestion of liver and lungs in the majority of cases and chronic passive congestion of liver and heart failu...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000167559.13502.9a