Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM)

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Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM)

Purpose. To study the safety of intravitreal injections of poly-N-isopropylacrylamide (pNIPAM) tissue adhesive in rabbit eyes. Methods. Twelve study rabbits received an intravitreal injection of 0.1 mL 50% pNIPAM in the right eye. Follow-up examinations included color fundus photography, fundus fluorescein angiography (FA), optical coherence tomography (OCT), and electroretinography (ERG). Subs...

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Poly-N-isopropylacrylamide (pNIPAM): a reversible bioadhesive for sclerotomy closure

PURPOSE To determine the safety and efficacy of poly-N-isopropylacrylamide, a thermoresponsive adhesive, for sutureless sclerotomy closure in rabbits. METHODS Eight rabbits were randomized into three groups: short-term acute, mid-term chronic, and long-term chronic studies. A corresponding control group in which the scleral wounds were sutured by 6-0 vicryl sutures was assigned for each study...

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Effect of Poly (n-isopropylacrylamide) “pnipam” on Hepatic Cells of Swiss Albino Mice, Mus Musculus

The present paper deals with the effect of polymeric compound poly (N-isopropyl acrylamide) “PNIPAM” for their toxicity on hepatic cells. The nanoparticle is a xenobiotic compound that accumulates in the liver for their metabolism. Non-metabolizing xenobiotic compounds such as “PNIPAM” produces anomalies in the hepatic cells. Certain enzymes such as ALT and ALP can be assayed for the hepatocyti...

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Rheological Characterization of the Thermal Gelation of Poly(n-isopropylacrylamide) and Poly(n-isopropylacrylamide) Co-acrylic Acid

Some systems show high miscibility in water at low temperatures while they phase separate at high temperatures. Before the macroscopic phase separation there is a strong turbidity, defined as clouding [1, 2]. At certain circumstances, namely above a critical concentration, the polymer system stays turbid with a gel-like appearance, without any macroscopic phase separation [3]. Gels defined in t...

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ژورنال

عنوان ژورنال: Journal of Ophthalmology

سال: 2016

ISSN: 2090-004X,2090-0058

DOI: 10.1155/2016/5356371