منابع مشابه
Gonadoblastoma arising in undifferentiated gonadal tissue within dysgenetic gonads.
PURPOSE The purpose of the study was to define the histological origin of gonadoblastomas, allowing the identification of high-risk patients. EXPERIMENTAL DESIGN Sixty paraffin-embedded gonadectomy or gonadal biopsy samples of 43 patients with gonadal dysgenesis were selected from our archives. We studied the morphology and immunohistochemical properties of the germ cells in 40 samples withou...
متن کاملHypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads.
The role of the human Y chromosome in the etiology of gonadoblastoma, a gonadal neoplasm, is considered and a two-part model is presented. According to this hypothesis: (1) There is a gene on the Y chromosome that strongly predisposes dysgenetic gonads to develop gonadoblastomas (Page, 1986) and (2) this postulated GBY gene (GonadoBlastoma locus on Y chromosome) has some physiological function ...
متن کاملOvarian sex cord tumor with annular tubules in a patient with Turner syndrome.
A case of ovarian sex cord tumor with annular tubules (SCTAT) in a 24-year old woman with Turner syndrome is presented. Close association of dysgenetic gonads and gonadoblastoma has been clearly documented, and there have been sporadic reports of patients with other gonadal tumors. To our knowledge, a case of SCTAT in a patient with 45,X/46,XX Turner syndrome has not been reported. On the basis...
متن کاملOccurrence of Multiple Tumors in a Patient.
An 81-year-old man initially presented with a right forearm mass that was found to be myxofibrosarcoma. In addition, he was found to have gastric and intragastric masses identified as neuroendocrine tumor (NET) and gastrointestinal stromal tumor (GIST; presenting synchronously), respectively, as well as a new left upper quadrant mass identified as desmoid tumor in the colon. The patient complai...
متن کاملTumors of Bilateral Streak Gonads in Patients with Disorders of Sex Development Containing Y Chromosome Material
The presence of Y chromosome material in patients with disorders of sex development (DSD) has been associated with a high risk of gonadoblastoma. Therefore, gonadectomy is recommended in females with bilateral streak gonads and Y chromosome material. The aim of this study was to present our experience with prophylactic gonadectomy in those patients and evaluate their risk of gonadal tumors. We ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1967
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(196708)20:8<1301::aid-cncr2820200814>3.0.co;2-4