OC20: Deep Intracerebral Electric Field Measurement with Stereoelectroencephalography during Transcranial Electrical Stimulations in Human in-vivo

Measuring the electric field generated in several deep brain structures during Transcranial electrical stimulation humans in-vivo. In addition, we investigated effects of TES intensities and montages on intracerebral EF. (TES) has shown for last decades promises as a treatment neurological psychiatric disorders. Its efficiency is related to amount (EF) magnitude delivered target. Very few studies (n=3) estimated in-vivo fields human. They relied mainly electrocorticographic recordings that require craniotomy did not precisely focus targeting cortical which can still lead some discussion about possibility reach structures. We applied alternating current stimulations simultaneously with (SEEG) 7 drug-resistant epileptic patients. Two low were used 6 patients (0.5 1mA) 15 different 1 patient. calculated by subtracting voltage measured contiguous contacts. found EF up 0.29, 0.38 0.54 V/m respectively amygdala, hippocampus, cingulate gyrus. Among 91 montage combinations, global difference was significant 65% cases. also confirmed experimentally proportional intensity. conclusion, at induces stochastic effects, achievable using intensities. highly correlated intensity depends montages.