Obstetric Pharmacokinetic Dosing Studies are Urgently Needed

Obstetric Pharmacokinetic Dosing Studies are Urgently Needed

Use of pharmacotherapy during pregnancy is common and increasing. Physiologic changes during pregnancy may significantly alter the overall systemic drug exposure, necessitating dose changes. A search of PubMed for pharmacokinetic clinical trials showed 494 publications during pregnancy out of 35,921 total pharmacokinetic published studies (1.29%), from the late 1960s through August 31, 2013. Cl...

Prospective validation of neonatal vancomycin dosing regimens is urgently needed

BACKGROUND Although vancomycin is frequently used to treat neonatal late-onset sepsis, there is no consensus on the optimal dosing regimen. Because many neonates needed dosing adaptation due to suboptimal trough values, the vancomycin dosing regimen in our neonatal department was changed during 2012. OBJECTIVE We aimed to document the need for validation of neonatal vancomycin dosing by explo...

Drug policy for methamphetamine use urgently needed.

Mental health systems research is urgently needed

Recent developments, including experience related to the development of WHO's World Health Report 2001, the WHO Atlas and the DCP Project related to Mental, Neurological, Developmental and Substance Abuse Disorders, indicate why advancing the interests of mental health is now so compelling. In order to deliver a high standard of mental health treatment and care WHO emphasizes the adoption of an...

Classification of periodicals in the CAPES QUALIS system: changes to the criteria are URGENTLY needed!

We start another year with this issue of the RBO, which now contains a greater number of studies. This was decided by the Editorial Board and the new directorate of the SBOT, in view of the ever greater number of studies sent for publication: instead of more issues, a journal with a greater number of studies. The Editorial Board has been renewed through the entry of Professors Akira Ishida, Hel...