Novel therapeutic approaches to post-infarction remodelling

Cathepsin-L contributes to cardiac repair and remodelling post-infarction.

AIMS Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction. METHODS AND RESULTS Experimental myocardial infarction (MI) was created in CTSL-deficient (Ctsl(-/-)) mice (B6 × FSB/GnEi a/a Ctsl(fs)/J) and wild-type litterma...

Effects of omacor on left ventricular remodelling consecutive to post myocardial infarction special issue-myocardial infarction

Ventricular remodelling is the main trigger of the development of heart failure. Therefore, the reduction of structural remodelling is known to prevent the development of heart failure. The aim of the present study was to investigate the effects of OMACOR, a well known mixture of EPA and DHA in an experimental model of heart failure induced by occlusion of left descending coronary artery and th...

Novel Gene Therapeutic Approaches to Brain Cancer

INTRODUCTION In the United States, approximately 17,000 people per year are diagnosed with brain tumors, the leading cause of death from cancers in children ages 1-15 year (1,2). Gliomas are the most prevalent type of brain tumors in adults, affecting 3.2/100,000 persons/yr in the United States (www.CBTRUS.org). In spite of advances in surgery, chemotherapy, and radiotherapy, the mean survival ...

Psoriasis: from pathogenesis to novel therapeutic approaches.

Psoriasis is one of the commonest chronic inflammatory disorders. Its cause is unknown, but a wealth of studies indicate that the disease results from a complex and dynamic interplay between genetic and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines pro...

Novel Therapeutic Approaches to Leishmania Infection