Novel therapeutic approaches to chronic kidney disease
نویسندگان
چکیده
منابع مشابه
Novel therapeutic approaches for chronic kidney disease due to glomerular disorders.
Improved understanding of glomerular disease mechanisms over the past decade has led to the emergence of new and targeted therapeutic strategies for chronic kidney disease (CKD). Most promising among these are the administration of recombinant mutated human angiopoietin-like 4, sialic acid-related sugars that induce sialylation in vivo, compounds related to Bis-T-23, and immune depletion of the...
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4 0 6 • H O S P I TA L P H A R M AC I S T Over the past few years the terminology used to describe kidney disease has changed. Previously, as the kidneys became less and less able to do their normal work of cleaning the blood and producing urine from the waste products, patients were said to have chronic renal or kidney failure. The term “end stage renal failure”was used to describe those patie...
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Polycystic kidney disease (PKD) is a common genetic disorder in which extensive epithelial-lined cysts develop in the kidneys. In previous studies, abnormalities of polycystin protein and its interacting proteins, as well as primary cilia, have been suggested to play critical roles in the development of renal cysts. However, although several therapeutic targets for PKD have been suggested, no e...
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Most patients we care for today suffer from more than one chronic disease, and multimorbidity is a rapidly growing challenge. Concomitant cardiovascular disease, renal dysfunction and diabetes represent a large proportion of all patients in cardiology, nephrology and diabetology. These entities commonly overlap due to their negative effects on vascular function and an accelerated atherosclerosi...
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In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondria...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2013
ISSN: 0306-5251
DOI: 10.1111/bcp.12124