Normal milk microbiome is reestablished following experimental infection with Escherichia coli independent of intramammary antibiotic treatment with a third-generation cephalosporin in bovines

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Normal milk microbiome is reestablished following experimental infection with Escherichia coli independent of intramammary antibiotic treatment with a third-generation cephalosporin in bovines

BACKGROUND The use of antimicrobials in food animals and the emergence of antimicrobial resistance are global concerns. Ceftiofur is the only third-generation cephalosporin labeled for veterinary use in the USA, and it is the drug of choice in the majority of dairy farms for the treatment of mastitis. Here, we use next-generation sequencing to describe longitudinal changes that occur in the mil...

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Longitudinal metagenomic profiling of bovine milk to assess the impact of intramammary treatment using a third-generation cephalosporin

Antimicrobial usage in food animals has a direct impact on human health, and approximately 80% of the antibiotics prescribed in the dairy industry are used to treat bovine mastitis. Here we provide a longitudinal description of the changes in the microbiome of milk that are associated with mastitis and antimicrobial therapy. Next-generation sequencing, 16 S rRNA gene quantitative real-time PCR,...

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Antibiotic resistance pattern and serotyping of Escherichia coli producing siderophore in people with urinary tract infection

Urinary tract infection is one of the most common bacterial infections of human. The most common agent of urinary tract infection is Escherichia coli . This study aims to determine the prevalence of uropathogenic E. coli urinary infection in human with different antimicrobial resistance, and quantitive and qualitative study of siderophore production and their association with the ability to cau...

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Experimental Intramammary Infection with a Strain of Escherichia coli Isolated from a Cow with Persistent E. coli Mastitis

Transient E. coli intramammary infections (IMI) are usually associated with rapid onset of clinical signs including mammary gland swelling and abnormal milk with rapid clearance of bacteria from milk. Conversely, reports have described strains of E. coli showing very different clinical trends. Persistent E. coli IMI are associated with mild clinical symptoms that disappear shortly after the ons...

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ژورنال

عنوان ژورنال: Microbiome

سال: 2017

ISSN: 2049-2618

DOI: 10.1186/s40168-017-0291-5