New actors in regulation of HIV-1 tat mRNA production
نویسندگان
چکیده
منابع مشابه
The Regulation of HIV-1 mRNA Biogenesis
The machinery regulating the transcription and processing of the human immunodeficiency virus type 1 (HIV-1) genome has been extensively studied for the past two decades, leading to the characterization of a complex set of interactions between viral and cellular factors. Our understanding of the basic molecular mechanisms regulating the expression of cellular genes has been greatly advanced by ...
متن کاملHIV-1 Tat vaccines.
The inexorable spreading of the HIV pandemic and the increasing deaths for AIDS in the developing countries underscore the urgency for an effective, safe and inexpensive vaccine against AIDS. Although many attempts have been made, a candidate vaccine of proven efficacy and safety in non-human primate models is not yet available. This is mostly due to HIV envelope (Env) variability and to the di...
متن کاملHuman DDX3 Interacts with the HIV-1 Tat Protein to Facilitate Viral mRNA Translation
Nuclear export and translation of intron-containing viral mRNAs are required for HIV-1 gene expression and replication. In this report, we provide evidence to show that DDX3 regulates the translation of HIV-1 mRNAs. We found that knockdown of DDX3 expression effectively inhibited HIV-1 production. Translation of HIV-1 early regulatory proteins, Tat and rev, was impaired in DDX3-depleted cells. ...
متن کاملHIV-1 Tat: Structure and Function
Most viruses encode functions for regulating genome transcription. Examples include the SV40 T-antigen, the adenovirus E1a protein, and the herpes virus immediate-early proteins. For the human immunodeficiency viruses (HIV), Tat functions similarly, though not identically, to those other activators. Over the past decade, we have learned much about Tat, both in structure and in function. The int...
متن کاملHTATIP (HIV-1 Tat interacting protein, 60kDa)
The Tip60 protein (isoform 2) is 513 amino acids long and its molecular weight is about 60 kDa. It was cloned and characterized in 1996 thanks to its interaction with the HIV-1 transactivator Tat protein. Isoform 1 produces a 546 amino acids long protein. Isoform 3 produces a 461 amino acids long protein. A novel isoform, Tip55, encodes a novel splicing variant corresponding to 103 amino acids ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Retrovirology
سال: 2009
ISSN: 1742-4690
DOI: 10.1186/1742-4690-6-s2-p46