Neurospora

Neurospora

were declining and now restricted to a signifi cantly smaller range (Proc. Natl. Acad. Sci. USA 108, 662). Looking for possible causes, the researchers found that the declining species had a signifi cantly higher prevalence of infection with Nosema. They also discovered that the declining populations had reduced genetic diversity compared with the stable ones. Establishing causal links between ...

Biotransformation of Hydrocortisone by Neurospora crassa

The ability of Neurospora crassa FGSC 4335 in the biotransformation of hydrocortisone was investigated. The microorganism produced two major metabolites after incubation with the substrate for seven days. Each microbial product was purified chromatographically and identified on the basis of spectral data. The products were identified as 11?,17?,20?,21-tetrahydroxypregn-4-en-3-one (II) and 11?-h...

MOLECULAR ANALYSIS OF THE SULFUR REGULATORY CIRCUIT OF NEUROSPORA CRASSA

The sulfur regulatory circuit of the filamentous fungus, Neurospora crassa, consists of a set of unlinked structural genes which encode sulfur catabolic and two major regulatory genes which govern their expression. The cys-3 regulatory gene encode a transacting regulatory protein which activates the expression of cys-14 and ars, whereas the other regulatory genes Scon-l and Scon-2 appear to...

Kynureninase from Neurospora: Purification

As part of a study of kynurenine metabolism in Neurospora crassa, the enzyme, kynureninase, has been investigated. Evidence from studies with mycelial pads suggests that tryptophan gives rise to kynurenine, which may be degraded to anthranilic acid (1). Kynurenine is also oxidized to hydroxykynurenine, which is converted to hydroxyanthranilic acid (2). The similarity of these reactions, i.e. th...

Quelling in Neurospora crassa.