Neuroprotective Effect of Alkylresorcinols from Wheat Bran in HT22 Cells: Correlation with <i>in vitro</i> Antioxidant Activity

Alkylresorcinols (ARs), which are phenolic lipids found in wheat bran, have attracted a considerable amount of attention because their antioxidant properties. However, the mechanism ARs for regulating neuroprotective activity remains unclear. The correlation between cellular effects HT22 cells and vitro were investigated. results showed that two main constituents crude C19:0 C21:0, was identified by high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. Pre-treatment with 400 μg/mL could protect from H2O2-induced damage involving low cell viability, leakage lactate dehydrogenase decreased superoxide dismutase activity. maximum radical scavenging ability DPPH•, ABTS•+, • •OH– 85.45%, 88.89%, 84.42% 87.36%. neuroprotection effect significantly correlated capacity, confirmed coefficients being 0.9988, –0.9974 0.9972. antioxidation potentially promoted further study is needed to clarify other behind benefits.