Neonatal abstinence syndrome after maternal methadone treatment.

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Neonatal abstinence syndrome after maternal methadone treatment.

Thirty two infants born to mothers taking methadone and 32 matched controls were studied to determine the incidence, timing, and frequency of persistence of withdrawal signs in infants born to maternal methadone users. Twelve (37%) infants received treatment for symptoms of withdrawal. The median length of time from birth to initiation of treatment was 23 hours (range 15-64 hours), the median l...

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Maternal methadone dose at delivery and neonatal abstinence syndrome.

OBJECTIVE To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS). STUDY DESIGN We performed a retrospective cohort study of pregnant women treated with methadone for opiate addiction who delivered live-born neonates between 1996 and 2006. Four dose groups, on the basis of total daily methadone dose, were compared (<or=80 mg/d, 81-1...

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Neonatal abstinence syndrome after methadone or buprenorphine exposure.

BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However, prenatal exposure to methadone is associated with a neonatal abstinence syndrome (NAS) characterized by central nervous system hyperirritability and autonomic nervous system dysfunction, which often requires medication and extended hospitalization. Buprenorphine, a parti...

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Treatment of neonatal abstinence syndrome.

Neonatal abstinence syndrome (NAS) is suffered by infants withdrawing from substances on which they have become physically dependent after in utero exposure. They may require prolonged treatment and spend weeks or even months in hospital. A wide range of drugs have been used to treat NAS. The efficacy of few, however, have been adequately investigated. Evidence suggests that opioids are the mos...

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Predicting length of treatment for neonatal abstinence syndrome in methadone-exposed neonates.

OBJECTIVE The objective of the study was to identify maternal variables predicting length of treatment for neonatal abstinence syndrome (NAS). STUDY DESIGN This was a retrospective cohort study of infants treated for NAS during 2000-2006 whose mothers were on methadone maintenance at delivery. Mixed-effects linear regression was used to examine the interaction of maternal and neonatal variabl...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood - Fetal and Neonatal Edition

سال: 1994

ISSN: 1359-2998,1468-2052

DOI: 10.1136/fn.71.3.f203