Natural Products as a Source of Inspiration for Novel Inhibitors of Advanced Glycation Endproducts (AGEs) Formation

Abstract Protein glycation, a post-translational modification found in biological systems, is often associated with core defect glucose metabolism. In particular, advanced glycation endproducts are complex heterogeneous sugar-derived protein modifications implicated the progression of pathological conditions such as atherosclerosis, diabetic complications, skin diseases, rheumatism, hypertension, and neurodegenerative diseases. Undoubtedly, there need to expand knowledge about antiglycation agents that can offer therapeutic approach preventing treating health issues high social economic importance. Although various compounds have been under consideration, little data from clinical trials available, lack approved registered agents. Next search for novel synthetic endproduct inhibitors, more efforts scientists focusing on researching natural origin. The main purpose this review provide thorough overview state scientific field products plant origin (e.g., extracts pure compounds) inhibitors formation period between 1990 2019. Moreover, objectives summary also include basic chemistry AGEs classification, pathophysiological significance AGEs, mechanisms inhibiting formation, examples several anti-AGEs drugs.