Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy
نویسندگان
چکیده
منابع مشابه
Natural Killer Cells for Immunotherapy – Advantages of the NK-92 Cell Line over Blood NK Cells
Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient's blood since they represent only 10% of the lymphocytes and are often dysfunctional. The alternative is to obtain cells from a healthy donor, which requir...
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Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we wil...
متن کاملRelationship between cell membrane potential and natural killer cell cytolysis in human hepatocellular carcinoma cells.
One of the body's natural defense mechanisms against tumor cells is lysis of the invading cell by cytotoxic T-cells and natural killer (NK) cells. Five human hepatocellular carcinoma cell lines were found to have different sensitivities to killing by peripheral blood monocytes in a 51Cr release assay. This killing was demonstrated to be due to NK cell lysis. Electrical recording measurements of...
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Immunotherapy of cancer must promote antitumor effector cells for tumor eradication as well as counteract immunoregulatory mechanisms which inhibit effectors. Immunologic therapies of cancer are showing promise, including dendritic cell-(DC-) based strategies. DC are highly malleable antigen-presenting cells which can promote potent antitumor immunity as well as tolerance, depending on the envi...
متن کاملEsophageal natural killer (NK)/T cell lymphoma of true natural killer cell origin.
A 53-year-old man with no prior medical history was transferred to our hospital because of a 2-month history of dysphagia with throat pain. A complete blood count showed hemoglobin 14.2g/dL, and white blood cell count 11890/mL, and other laboratory findings were within normal limits. An enhanced computed tomography (CT) scan showed diffuse thickening of the esophageal wall without regional lymp...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2015
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2015.41