NASH-related and cryptogenic cirrhosis similarities extend beyond cirrhosis

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Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis

AIM To characterize natural history of cryptogenic cirrhosis (CC) and compare its clinical features and outcomes to those of hepatitis C virus (HCV)-related cirrhosis. METHODS A prospective cohort of 102 consecutive patients at their first diagnosis of CC were enrolled in this study. The clinical data and outcomes were compared to an age- and Child-Pugh class-matched cohort of 110 patients wi...

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Cryptogenic cirrhosis in relapsing polychondritis.

Though the first documented case was described by Jaksch-Wartenhorst (1923), the name 'relapsing polychondritis' was suggested by Pearson, Kline and Newcomer as late as 1960. The extreme rarity of the condition and its possible confusion with other common conditions in Bangladesh, for example, leprosy, gout and pyogenic conditions of the pinna prompted us to report this case. In addition, the p...

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NASH‐related cirrhosis: An occult liver disease burden

Nonalcoholic fatty liver disease (NAFLD) is reaching epidemic proportions. It is currently the most common cause of chronic liver disease worldwide, with a prevalence of 25%-30% of the general population. Recent estimates indicate that over 64 million people may have NAFLD in the United States while Europe has an estimated 53 million affected individuals. These figures point to a daunting and e...

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Pulmonary arteriovenous malformation in cryptogenic liver cirrhosis.

The cause in 10 - 20% cases of liver cirrhosis (LC) cannot be elucidated, and are thus termed cryptogenic. Pulmonary arteriovenous malformations (PAVMs) are relatively rare, but the most common anomaly involving the pulmonary tree. Although the rare correlation between LC and PAVM is well-known, there have been no reports of PAVMs occurring in cryptogenic LC. We report a case of PAVM that occur...

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HFE Gene Mutations in Cryptogenic Cirrhosis Patients

In Western countries, HFE-linked hereditary hemo-chromatosis (HH) is considered to be the most common cause of iron overload. The HFE gene, first identified in 1996, is located on the short arm of chromosome 6. The majority of patients with phenotypic HH are homozy-gous for the C282Y mutation, a major mutation of the HFE gene, whereas compound heterozygosity (C282Y/ H63D) is found in patients w...

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ژورنال

عنوان ژورنال: Journal of Hepatology

سال: 2018

ISSN: 0168-8278

DOI: 10.1016/j.jhep.2018.05.016