Myeloperoxidase in human neutrophil host defence
نویسندگان
چکیده
منابع مشابه
Penicillin-binding protein inactivation by human neutrophil myeloperoxidase.
Myeloperoxidase (MPO), H2O2, and chloride comprise a potent antimicrobial system believed to contribute to the antimicrobial functions of neutrophils and monocytes. The mechanisms of microbicidal action are complex and not fully defined. This report describes the MPO-mediated inactivation, in Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, of a class of cytoplasmic membrane...
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Myeloperoxidase is a cationic protein present in the azurophilic granules of human neutrophils and constitutes 2% to 5% of neutrophil protein by weight. Despite extensive characterization of the functional importance of myeloperoxidase in the microbicidal activity of neutrophils, there is no consensus regarding the subunit composition of this enzyme or the presence of genetic polymorphism. Usin...
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He also observed that the increase in MPO preceded the development of macrocytosis in megaloblastic anemia, thus suggesting that the threshold for the development of macrocytosis is higher than that for the development of increased MPO activity. We studied neutrophil MPO activity using the method of Herzog and Fahimi' and neutrophil MPO scoring by the method of Kaplow'in 40 chronic smokers (blo...
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Activated neutrophils use myeloperoxidase (MPO) to generate an array of potent toxic oxidants. In the current studies we used genetically altered mice deficient in MPO to investigate the role of the enzyme in host defense against the Gram-negative bacterium Klebsiella pneumoniae, an important human pathogen. For comparison, we used mice deficient in the antimicrobial molecule, neutrophil elasta...
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We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean c...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2014
ISSN: 1462-5814
DOI: 10.1111/cmi.12312