Muscle and adipose tissue insulin resistance: malady without mechanism?
نویسندگان
چکیده
منابع مشابه
Adipose Tissue Inflammation and Insulin Resistance
A sustained increase in body mass, particularly fat mass, an unhealthy diet and a sedentary lifestyle trigger metabolic alterations such as metabolic syndrome, obesity, and type 2 diabetes mellitus (2DM). These metabolic conditions increase the cardiovascular disease risks and have become epidemic public health problems (Grundy 2002). Individuals who are overweight and obese are associated with...
متن کاملAdipose tissue and the insulin resistance syndrome.
Obesity is associated with insulin resistance. Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism ...
متن کاملAdipose tissue ELVs induce insulin resistance Adipose tissue exosome-like vesicles mediate activation of macrophage- induced insulin resistance A running title: Adipose tissue ELVs induce insulin resistance
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294 Department of Nutrition, University of Alabama at Birmingham, Birmingham, AL 35294 ...
متن کاملInsulin resistance causes inflammation in adipose tissue.
Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose...
متن کاملBrown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increase...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2019
ISSN: 0022-2275
DOI: 10.1194/jlr.r087510