Muller cells of chicken retina synthesize 11-cis-retinol
نویسندگان
چکیده
منابع مشابه
Muller cells of chicken retina synthesize 11-cis-retinol.
The amounts of endogenous retinyl palmitate, retinol and retinaldehyde were measured in the neural retina and retinal pigment epithelium (RPE) of predominantly cone (chicken), rod (rat) and more mixed (cat, human) retinae. The ratio of 11-cis to all-trans isomers of retinyl palmitate and retinol in the neural retina and the RPE increases progressively with the increase in diurnality of the spec...
متن کاملMuller cells are living optical fibers in the vertebrate retina.
Although biological cells are mostly transparent, they are phase objects that differ in shape and refractive index. Any image that is projected through layers of randomly oriented cells will normally be distorted by refraction, reflection, and scattering. Counterintuitively, the retina of the vertebrate eye is inverted with respect to its optical function and light must pass through several tis...
متن کاملPreferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein.
In photoreceptor cells of the retina, photoisomerization of 11-cis-retinal to all-trans-retinal triggers phototransduction. Regeneration of 11-cis-retinal proceeds via a complex set of reactions in photoreceptors and in adjacent retinal pigment epithelial cells where all-trans-retinol is isomerized to 11-cis-retinol. Our results show that isomerization in vitro only occurs in the presence of ap...
متن کاملCloning and expression of a cDNA encoding bovine retinal pigment epithelial 11-cis retinol dehydrogenase.
PURPOSE Identification of a 32-kd protein in the bovine retinal pigment epithelium. METHODS A bovine retinal pigment epithelium cDNA library was constructed in the bacteriophage lambda ZAP Express. A monoclonal antibody, designated 21-C3/AV, was used to isolate the cDNA encoding the 21-C3/AV antigen. A positive full-length clone, designated 21-C3RDH/CD, was sequenced. Northern blot analysis w...
متن کامل1242 Cloning and expression of a cDNA encoding bovine retinal pigment epithelial 11-cis retinol dehydrogenase
a Tdenzification of a 32 kDaiton protein in the bovine retinal pigment epithelium. Hethods A bovine retinal pigment epithelium cDNA library wa* constructed and immunologically screened with monoclonai antibody 21-C3/AV. A positive full-length clone, 21-C3RDH/CD, wan sequenced. Northern blot analysis were performed to analyze the tissue expression pattern. In order 'co analyze the function of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1992
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2850907