MP03-17 ORAL MUCOSA GRAFTING (OMG) OR EXCISION AND PRIMARY ANASTOMOSIS (EPA) FOR THE TREATMENT OF RADIATION-ASSOCIATED URETHRAL STRICTURES: COMPARATIVE ANALYSIS

You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Urethral Reconstruction (including Stricture, Diverticulum) I (MP03)1 Sep 2021MP03-17 ORAL MUCOSA GRAFTING (OMG) OR EXCISION AND PRIMARY ANASTOMOSIS (EPA) FOR THE TREATMENT OF RADIATION-ASSOCIATED URETHRAL STRICTURES: COMPARATIVE ANALYSIS Matthias D. Hofer, Dmitriy Nikolavsky, Connor Policastro, Brian J Flynn, Kirk Redger, Allen F. Morey, Sarah Sanders, Avery Wolfe, Aziz Shaaban, Jay Simhan, Curran Uppaluri, Erick Ramirez, Javier Angulo, Krishnan Venkatesan, Akio Horiguchi, Cooper Benson, Ayman Elmasri, Diana Bowen, Chris M. Gonzalez, Ryan Dornbier, and Francisco E. Martins HoferMatthias Hofer More articles by this author , NikolavskyDmitriy Nikolavsky PolicastroConnor Policastro FlynnBrian Flynn RedgerKirk Redger MoreyAllen Morey SandersSarah Sanders WolfeAvery Wolfe ShaabanAziz Shaaban SimhanJay Simhan UppaluriCurran Uppaluri RamirezErick Ramirez AnguloJavier Angulo VenkatesanKrishnan Venkatesan HoriguchiAkio Horiguchi BensonCooper Benson ElmasriAyman Elmasri BowenDiana Bowen GonzalezChris Gonzalez DornbierRyan Dornbier MartinsFrancisco View All Author Informationhttps://doi.org/10.1097/JU.0000000000001964.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION OBJECTIVE: Radiation-associated strictures occurring after radiotherapy for prostate cancer usually affect the bulbomembranous urethra. These are more challenging repair an increased rate recurrence. While EPA has traditionally been preferred surgical repair, use OMG these emerging. We analyze both techniques aim identify those patients that better suited either technique. METHODS: In a multicentric international study we collected 181 with radiation-associated which 75 underwent dorsal onlay 106 urethroplasties between 2004 2020. Mean follow-up was 46.64 months. RESULTS: Three were lost follow-up. 94/178 (52.5%) had treated external beam radiation, 57 (31.9%) brachytherapy, 27 (15.1%) combination both. stricture length 2.82 cm. time 167.5 minutes mean blood loss 174.5 ml. Overall, 141/175 (80.6%) experienced durable urethral patency. There no difference in patient characteristics such as co-morbidities, specifically hypertension, diabetes, or lung disease cohorts, there also frequency prior endoscopic interventions operative parameters time. Patients significantly longer than (3.72 vs. 2.14 cm (p<0.001). Notably, post-op post-void dribbling, penile pain, erectile dysfunction. urethroplasty lower risk recurrence (8/69 (11.6%) 26/106 (24.5%) p=0.035) albeit cohort shorter (39.1 months vs 51.8; p=0.014). undergoing higher if they diabetes (p=0.031) body mass index (BMI, p=0.048) being associated borderline significance (p=0.053). found specific factors among patients. Dose radiation did not impact success CONCLUSIONS: Both very successful treating strictures. grafting appears be BMI, may decreased perfusion facilitating EPA. Source Funding: None © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e27-e28 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...