Morphological diagnostics of serrated colorectal neoplasias
نویسندگان
چکیده
منابع مشابه
Neoplasias of the colorectal crypts.
Colorectal cancers are often preceded by noninvasive neoplasias arising in the surface epithelium, namely tubular, tubulovillous and villous adenomas. That neoplasias may also arise in the colorectal crypts is less well known. Between 1998 and 2002, colonoscopies, rectoscopies and colorectal surgical specimens from 8647 patients were received at this Department for histological diagnosis. The m...
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The concept of serrated colorectal neoplasia has become recognised as a key process in the development of colorectal cancer (CRC) and an important alternative pathway to malignancy compared with the long established ‘adenoma-carcinoma’ sequence. Increasing recognition of the morphological spectrum of serrated lesions has occurred in parallel with elucidation of the distinct molecular genetic ch...
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Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Previously thought benign and unimportant, there is now compelling evidence that SPs are responsible for a significant percentage of incident colorectal cancer worldwide. In contrast to conventional adenomas, which tend to be slow growing and polypoid, SPs have unique features that undermine curren...
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AIMS Maspin, a 42-kDa serine proteinase inhibitor, is a tumor suppressor protein that stimulates apoptosis and inhibits motility, invasion and cancer metastasis. Mutant maspin leads to partial loss of tumor suppressor function, decreased susceptibility to apoptosis and to malignant progression. We recently found maspin expression (ME) in the cytoplasm of serrated colonic lesions, such as hyperp...
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Colorectal cancer (CRC) is the third most commonly diagnosed type of malignancy in males and the second in females, with over 1.2 million new cancer cases and 608,700 deaths estimated to have occurred in 2008 [1]. Sporadic CRC accounts for 75% of the total CRC cases, with colorectal adenoma regarded as the precursor lesion (adenoma-carcinoma sequence) [2]. Despite the major advances in the scre...
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ژورنال
عنوان ژورنال: ScienceRise
سال: 2015
ISSN: 2313-8416,2313-6286
DOI: 10.15587/2313-8416.2015.47561