Monogenic and Monoallelic Expression of Odorant Receptors
نویسندگان
چکیده
منابع مشابه
Monogenic and Monoallelic Expression of Odorant Receptors.
Odorant receptors (ORs) belong to a large gene family of rhodopsin-like G protein-coupled receptors (GPCRs). The mouse OR gene family is composed of ∼1000 OR genes, and the human OR gene family is composed of ∼400 OR genes. The OR genes are spread throughout the genome, and can be found in clusters or as solitary genes in almost all chromosomes. These chemosensory GPCRs are expressed in highly ...
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In olfactory neurons, expression of a single odorant receptor (OR) from a repertoire of >1000 genes is required for odor coding and axonal targeting. Here, we demonstrate a role for OR protein as an essential regulator in the establishment of monoallelic OR expression. An OR-promoter-driven reporter expresses in a receptor-like pattern but, unlike a native OR, is coexpressed with an additional ...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2016
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.116.104745