Monocyte chemoattractant protein-1 and coronary artery disease

Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease.

BACKGROUND Monocyte chemoattractant protein-1 (MCP-1) is involved in the recruitment of monocytes into the arterial vessel wall as one of the major events leading to atherosclerotic vascular diseases, such as coronary artery disease (CAD). METHODS AND RESULTS The study group comprised 263 volunteers aged between 18 and 85 years who were admitted to hospital or clinic for scheduled invasive an...

Monocyte chemoattractant protein-1 concentration in coronary sinus blood and severity of coronary disease.

Concentration in Coronary Sinus Blood and Severity of Coronary Disease To the Editor: We have read the excellent article by de Lemos et al1 on the prognostic significance of the monocyte chemoattractant protein-1 (MCP-1) in the long-term clinical outcomes in patients with acute coronary syndromes. Because MCP-1 has been shown to be related to atherosclerosis development,2 we measured the concen...

Monocyte Chemoattractant Protein-1 Synthesis

Serum Levels of Monocyte Chemoattractant Protein-1 and All-Cause and Cardiovascular Mortality among Patients with Coronary Artery Disease

BACKGROUND Monocyte chemoattractant protein-1 (MCP-1) is an important chemokine at multiple phases of atherosclerosis in animals, but human studies are few and inconsistent. The aim of this study is to investigate the association of serum MCP-1 with all-cause and cardiovascular disease (CVD) mortality among coronary artery disease (CAD) patients and determine whether this biomarker can add seco...

Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 levels, and the risk of coronary artery disease.

OBJECTIVE In humans, evidence about the association between levels of monocyte chemoattractant protein-1 (MCP-1), its coding gene chemokine (C-C motif) ligand 2 (CCL2), and risk of coronary artery disease (CAD) is contradictory. METHODS AND RESULTS We performed a nested case-control study in the prospective EPIC-Norfolk cohort investigating the relationship between CCL2 single-nucleotide poly...