Molecular Regulation of Canalicular ABC Transporters
نویسندگان
چکیده
منابع مشابه
The role of canalicular ABC transporters in cholestasis.
Cholestasis, a hallmark feature of hepatobiliary disease, is characterized by the retention of biliary constituents. Some of these constituents, such as bile acids, inflict damage to hepatocytes and bile duct cells. This damage may lead to inflammation, fibrosis, cirrhosis, and eventually carcinogenesis, sequelae that aggravate the underlying disease and deteriorate clinical outcome. Canalicula...
متن کاملStructure of ABC transporters.
ABC (ATP-binding cassette) transporters are primary active membrane proteins that translocate solutes (allocrites) across lipid bilayers. The prototypical ABC transporter consists of four domains: two cytoplasmic NBDs (nucleotide-binding domains) and two TMDs (transmembrane domains). The NBDs, whose primary sequence is highly conserved throughout the superfamily, bind and hydrolyse ATP to power...
متن کاملHepatobiliary ABC transporters: physiology, regulation and implications for disease.
The liver plays a key role in the metabolic conversion and elimination of endo- and xenobiotics. Hepatobiliary transport of many of these compounds is mediated by several ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of the hepatocyte. Impaired function of these ABC transporters leads to impaired bile formation or cholestasis and mutations in these genes are asso...
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Mitochondria are essential organelles of most eukaryotic cells including fungi, invertebrates, vertebrates and plants. They perform various processes such as oxidative phosphorylation, the tricarboxylic acid cycle, fatty acid oxidation, the biosynthesis of various amino acids, the generation of iron-sulfur (Fe/S) clusters and their insertion into apoproteins, as well as partial reactions of hem...
متن کاملPeroxisomal ABC transporters.
The set of proteins found in the membranes of mammalian peroxisomes includes four half ABC transporters (ALDP, ALDR, PMP70, P70R) comprising a distinct subset of the superfamily of ABC transporters designated subfamily D. Each has an N-terminal hydrophobic transmembrane domain with multiple transmembrane segments (TMS) and a hydrophilic C-terminal half containing a nucleotide-binding domain (NB...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22042113