Molecular Aspects of Drug-Induced Gingival Overgrowth: An In Vitro Study on Amlodipine and Gingival Fibroblasts

Amlodipine-induced gingival overgrowth.

Amlodipine is a calcium channel blocker used in the management of angina and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compounded by the patient's existing periodontal condition. In all 3 patients, there was sequestration of amlodipine in thei...

Drug-induced Gingival Overgrowth

Many terms have been used to describe gingival overgrowth. The expression gingival hyperplasia (“abnormal increase in the number of normal cells in a normal arrangement in an organ or tissue, which increase in volume”) and gingival hypertrophy (“enlargement or overgrowth of an organ or part due to an increase in size of its constituent cells”) have been also used, although gingival overgrowth i...

Prevalence of Amlodipine-induced Gingival Overgrowth

Amlodipine- induced gingival overgrowth: a case report.

Drug-induced gingival overgrowth occurs in genetically susceptibIe individuals as a side effect of various drugs. There is a gross disfiguring enlargement of gingiva mostly in the anterior region leading to difficulty in mastication, speech and maintenance of oral hygiene. In this case report, amlodipine-induced gingival enlargement and its management are discussed. Drug substituion, appropriat...

Amlodipine induced gingival overgrowth: A case report

Introduction: Drug-induced gingival overgrowth (DIGO) remains a significant problem for the dental clinicians and the periodontologists. Patients medicated with certain drugs may be implicated in this unwanted side effect, which may interfere with esthetics, mastication or speech. Case Report: The case presented here is a 60-year-old female patient with drug induced gingival enlargement. Patien...