Modulation of PHLPP activity: screening for specific inhibitors
نویسندگان
چکیده
منابع مشابه
Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase.
Esterases catalyze the hydrolysis of therapeutic drugs containing esters or amides in their structures. Human carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes that catalyze the hydrolysis of drugs in the liver. Characterization of the enzyme(s) responsible for drug metabolism is required in drug development and to realize optimal drug therapy. Because multiple ...
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Antioxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress. A variety of free radical scavenging antioxidants exist within the body which many of them are derived from dietary sources like fruits, vegetables and teas. In this study the antioxidant activity and radical scavenging activity of methanolic extracts of s...
متن کاملScreening of Thirteen Medicinal Plant Extracts for Antioxidant Activity
Antioxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress. A variety of free radical scavenging antioxidants exist within the body which many of them are derived from dietary sources like fruits, vegetables and teas. In this study the antioxidant activity and radical scavenging activity of methanolic extracts of s...
متن کاملDiscovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening
PH domain Leucine-rich repeat protein phosphatase (PHLPP) directly dephosphorylates and inactivates Akt and protein kinase C, poising it as a prime target for pharmacological intervention of two major survival pathways. Here we report on the discovery of small molecule inhibitors of the phosphatase activity of PHLPP, a member of the PP2C family of phosphatases for which there are no general pha...
متن کاملIn vitro Screening of Bryophytes for Antimicrobial Activity
Background: Bryophytes, the previous land plants posses medicinally important bioactive compounds but with little information. Traditionally the bryophytes plants posses some bioactive components and therefore used throughout the world as drugs and remedies to cure the various diseases. Objectives: Evaluation of antimicrobial effect of mentioned bryophytes on some pathogenic microorganisms. ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.lb289