Models for the Sensitivity of Voltage Gated K Channels to Bilayer Mechanical Stresses
نویسندگان
چکیده
منابع مشابه
Inactivation of voltage-gated cardiac K+ channels.
Inactivation is the process by which an open channel enters a stable nonconducting conformation after a depolarizing change in membrane potential. Inactivation is a widespread property of many different types of voltage-gated ion channels. Recent advances in the molecular biology of K+ channels have elucidated two mechanistically distinct types of inactivation, N-type and C-type. N-type inactiv...
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Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentified temperature-sensing domain. Here we report that the homologous voltage-gated potassium (Kv) channels also exhibit high temperature sensitivi...
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Typical single channel recordings in voltage-dependent K channels show two simple conductance states: open or shut. Considering the fact that K channels are assembled with four identical subunits, the classical interpretation has been that the conduction pathway is not formed unless all four subunits are in their active positions. In fact, this agrees with the molecular interpretation of the op...
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Hypoxic pulmonary vasoconstriction is initiated by inhibiting one or more voltage-gated potassium (Kv) channel in the vascular smooth muscle cells (VSMCs) of the small pulmonary resistance vessels. Although progress has been made in identifying which Kv channel proteins are expressed in pulmonary arterial (PA) VSMCs, there are conflicting reports regarding which channels contribute to the nativ...
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؉ Channels labeling studies of KcsA suggest that K ϩ channels may gate by rotating the inner helices that line the pore (Per-ozo et al., 1999). In this model, the degree of rotation of the helices regulates the aperture of the inner mouth of the pore that opens and closes like the shutters of a San Francisco, California 94143 camera. For voltage-gated K ϩ channels, this model is broadly consist...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.2598