Mode of Action of Illudin S

evolution and mode of action of pulsed radiofrequency

Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues.

Acylfulvenes (AFs) are a class of antitumor agents with favorable cytotoxic selectivity profiles compared to their natural product precursor, illudin S. Like many alkylating agents, illudin S and AFs readily react with thiol-containing small molecules such as cysteine, glutathione and cysteine-containing peptides; reduced cellular glutathione levels can affect illudin S toxicity. Glutathione re...

Mode of Action

Being impermeable to folic acid, many bacteria must rely on their ability to synthesise folate from PABA, Pteridine, and glutamate in contrast the mammalian in cells cannot synthesise folic acid and must obtain preformed folate as a vitamin in their diet. The sulphonamides are structurally similar to PABA, the sulphonamides competitively inhibit dihydropteroate synthetase, the enzyme that catal...

Preclinical antitumor activity of 6-hydroxymethylacylfulvene, a semisynthetic derivative of the mushroom toxin illudin S.

6-Hydroxymethylacylfulvene (HMAF; MGI 114) is a novel semisynthetic antitumor agent derived from the sesquiterpene mushroom toxin illudin S. In vitro cytotoxicity determinations produced IC50 concentrations (concentrations required for 50% inhibition of growth) ranging from 160 nM in sensitive MCF-7 human mammary carcinoma cells to 17 microM in relatively insensitive murine B16 melanoma cells. ...

Mode of action of tomaymycin.

The mode of action of tomaymycin (TM) which is a new antibiotic with antitumor activity was studied. Inhibition of the incorporation of labeled precursors into the acid-insoluble fraction of Bacillus subtilis cells indicated that TM inhibits nucleic acids biosynthesis, while having relatively little effect on protein synthesis. TMdisplaced methyl green (MG) from a MG-DNA complex and a TM-DNA co...