Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI
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چکیده
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Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI
Mitochondrial Ca(2+) uptake, central to neural metabolism and function, is diminished in aging whereas enhanced after acute/sub-acute traumatic brain injury. To develop relevant translational models for these neuropathologies, we determined the impact of perturbed mitochondrial Ca(2+) uptake capacities on intrinsic brain activity using clinically relevant markers. From a multi-compartment estim...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0063317