منابع مشابه
A Review of Mitochondrial Biogenesis and Cellular Response
Abstract Background and Objectives Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover of this process. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly pla...
متن کاملMitochondrial Biogenesis and Maturation
The human heart consumes kilogram quantities of ATP daily to support persistent pump function. The vast majority of this ATP (>95%) is produced by mitochondrial oxidative phosphorylation (OXPHOS). Mitochondrial fatty acid oxidation (FAO) accounts for ≈60% to 90% of ATP production, whereas catabolism of carbohydrates contributes the remaining 10% to 40%. To support this high demand for ATP produ...
متن کاملMYC and mitochondrial biogenesis.
Mitochondria, the powerhouses of the cell, face two imperatives concerning biogenesis. The first is the requirement for dividing cells to replicate their mitochondrial content by growth of existing mitochondria. The second is the dynamic regulation of mitochondrial content in response to organismal and cellular cues (e.g., exercise, caloric restriction, energy status, temperature). MYC provides...
متن کاملTERRA biogenesis, turnover and implications for function.
Telomeres are heterochromatic structures at the ends of eukaryotic chromosomes. As other heterochromatin regions, telomeres are transcribed, from the subtelomeric region towards chromosome ends into the long non-coding RNA TERRA. Telomere transcription is a widespread phenomenon as it has been observed in species belonging to several kingdoms of the eukaryotic domain. TERRA is part of telomeric...
متن کاملNitric oxide and mitochondrial biogenesis.
The characteristic structural organization of mitochondria is the product of synthesis of macromolecules within the mitochondria together with the import of proteins and lipids synthesized outside the organelle. Synthetic and import processes are required for mitochondrial proliferation and might also facilitate the growth of pre-existing mitochondria. Recent evidence indicates that these event...
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ژورنال
عنوان ژورنال: Cell Calcium
سال: 2008
ISSN: 0143-4160
DOI: 10.1016/j.ceca.2007.12.004