MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophila

The hematopoietic system plays a crucial role in immune defense response and normal development, it is regulated by various factors from other tissues. dysregulation of hematopoiesis associated with melanotic mass formation; however, the molecular mechanisms underlying this process are poorly understood. Here, we observed that overexpression miR-274 fat body resulted formation masses. Moreover, abnormal activation JNK JAK/STAT signaling pathways was linked to these consequences. In addition defect, larval decreased total tissue size, leading reduction weight. miR-274-5p found directly suppress expression found-in-neurons (fne), which encodes an RNA-binding protein. Similar effects overexpression, fne depletion led growth reduction. Collectively, regulatory fne–JNK axis control.