Microdeletions, Rearrangements, and Cancer Susceptibility
نویسندگان
چکیده
منابع مشابه
Chromosomal rearrangements in cancer
Many cancers exhibit chromosomal rearrangements. These rearrangements can be simple with a single balanced fusion preserving the proper complement of genetic information or they can be complex with one or more fusions that distort this balance. A range of technological advances has improved our ability to detect and understand these rearrangements leading to speculation of causal mechanisms inc...
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I T IS NOW WELL established that human tumors, particularly leukemias and lymphomas, are characterized by nonrandom chromosomal abnormalities. During the past 2 years, a number of proto-oncogenes and transforming genes have been mapped to the chromosomal breakpoints involved in the specific structural rearrangements. Experimental evidence obtained recently suggests that the genes located at the...
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Genomic rearrangements in inherited disease and cancer involve gross alterations of chromosomes or large chromosomal regions and can take the form of deletions, duplications, insertions, inversions or translocations. The characterization of a considerable number of rearrangement breakpoints has now been accomplished at the nucleotide sequence level, thereby providing an invaluable resource for ...
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Motivation The traditional view of cancer evolution states that a cancer genome accumulates a sequential ordering of mutations over a long period of time. However, in recent years it has been suggested that a cancer genome may instead undergo a one-time catastrophic event, such as chromothripsis, where a large number of mutations instead occur simultaneously. A number of potential signatures of...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2016
ISSN: 1059-7794
DOI: 10.1002/humu.22864