mGluR5, CB1 and neuroprotection
نویسندگان
چکیده
منابع مشابه
mGluR5, CB1 and neuroprotection
The metabotropic glutamate receptor 5 (mGluR5) is a Gαq/11-coupled receptor, mainly found at the postsynaptic site. mGluR5 stimulation leads to the activation of phospholipase Cβ1 (PLCβ), promoting diacylglicerol (DAG) and inositol 1,4,5-trisphosphate (IP3) formation, which leads to the release of Ca2+ from the intracellular stores and the activation of protein kinases, including protein kinase...
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Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impairment. Since glial activation plays a key role in the development of this damage, it seems that controlling it could be beneficial and could lead to ne...
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We investigated whether glutamate receptor subunit 2 (GluR2) is involved in EA pretreatment-induced neuroprotection via cannabinoid CB1 receptors (CB1R) after global cerebral ischemia in mice. Two hours after electric acupuncture (EA) pretreatment, global cerebral ischemia (GCI) was induced by bilateral common carotid artery occlusion (BCCAO) for 20 min. The GluR2 expression was examined in the...
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Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the cellular actions of this receptor in the nucleus accumbens (NAc). Although mGluR5 has the potential to regulate neurons directly, recent studies have shown the importance of mGluR5 in regulating Ca(2+) signaling in astrocytes and, as a con...
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Neuron loss and neurodegeneration are the common denominators of what are known as neurodegenerative diseases. Although the clinical manifestations of some neurodegenerative diseases are mainly associated with ageing, it is believed that onset of disease and neuronal death occurs progressively through life, well before the first symptoms appear. So, one of the main dilemmas regarding neurodegen...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.14086